* General view of the applications and uses of electrochemistry in the industrial world and in research * Reminder on electrochemical reactions, set-ups, notions of faradic and capacitive currents, ohmic drop, power lines. * Notions of electron transfer and introduction of the kinetic parameters (System slow/fast, constant electrokinetic, diffusion coefficient) * Voltamperometric methods for species in solution in different systems, chronopotentiometry * Application to simple electronic transfers, chemical reactions coupled to electron transfers, electrocatalysis.

Concepts de base de la Chimie de Synthèse

Determination and/or confirmation of molecular or macromolecular structures of organic compounds using cross-analysis methods. Emphasis will be placed on the interpretation of the spectra and the use of data for the characterization of compounds and will be limited to brief theoretical recalls. Analysis of molecular or macromolecular organic compounds by UV, IR, RAMAN, NMR, MS, and fluorimetry.

Theoretical courses dealing with the fundamental quantities of chromatography, chromatographic equipment, modes of chromatography, and an introduction to electrokinetic methods.

We will work out the spoken english and the written english. We will mainly focus on the analysis of scientific docuements.

Notions of optimization and improvement in process engineering: process analysis, implementation, SMED, inventory management, LEAN, 5s, 6-sigma and other, KPI and SMART, HAZOP.

Two sections : Retrosynthesis and asymetric synthesis. Basic principles of the disconection approach with the concept of synthetic equivalent for the elaboration of the carbon bones in natural products. Asymetric syntheses from chiral reagents, catalysts or chiral auxiliaries.

Knowledge and understanding of the specific behaviors of polymers: isolated macromolecule, macromolecule in the mass of amorphous polymer, semi-crystalline polymers, rubber elasticity.

Definition and history of nanoscience and nanotechnology. Introduction to synthesis and characterisation of materials. Special properties of nanomaterials. Fields of applications. Nanomaterials in everyday life

Acquisition of conceptual and technical knowledge relating to the production of molecules of interest by microorganisms (bacteria and fungi). Mastering the techniques of analysis and quality control and safety.

Acquisition of conceptual and technical knowledge relating to the production of proteins of interest via various heterologous production systems.

Electrons in atoms : electronic configurations and atomic orbitals. Quantum approach of chemical bonding : molecular orbitals. OM diagrams of homo and heteronuclear diatomics. Polyatomic molecules : fragment methods. Pi system study : Hückel method.

Notions on computers, algorithm basics, programming structure, basic instructions. Tests, loops, in/out, functions, polynom interpolation, numerical intergration, node search. Applications to matter sciences.

Introduction to modelisation of atoms, molecules and solids structues. Optimisation and visualisation of molecular and cristallographic structures. Applications to the reactivity of simple systems, Lewis acid/base approach, frontier orbitals approach. Use of simple codes and applets of molecular simulations and modelling.

Energetic exchanges in environmental reactions : C and N cylces; Hydeolysis kinetics in natural waters. Main processes and reactions in Environment. Oxidation reactions. Environmental photochemistry. Chemical elements and environmental problems. Toxic organic compounds : pesticides; PCB; HAP, dioxins. Chemical pollution (air, water).

Knowledge of the NMR principles and understanding of phenomena related to the chemical structure, conformation and local dynamics of complex molecules. Principles of NMR, Notions of chemical shift and spin-spin coupling, Modes of acquisition of Spectra 1 d 1 H and 13 c NMR, molecular origins of two-dimensional NMR, NMR relaxation, openings to other applications of NMR.

Study of Colloids: interparticle Forces, stability of colloids, Interfacial tension, physical chemistry of surfactants: micelles, surfactants at solid and liquid interfaces , emulsions, foams.

Surface and interface definitions. Mechanisms of phenomena at interfaces, balance of forces involved (surface tension, wettability...). Familiarizing yourself with the tools for the characterization of surfaces: microscopy (MOP, SEM, AFM), spectroscopy (XPS, FTIR, raman...), Optics (ellipsometry, SPR) and gravimetry (QCM)...

To develop the initiative and the autonomy of chemists towards concrete practical problems by integrating precise data and specifications. This will be done in the form of an experimental laboratory project or a bibliographic project. Attend a lecture cycle and report back.

We will work out the spoken english and the written english. We will mainly focus on the analysis of scientific docuements.

Master the methods of synthesis of cyclic compounds according to the ionic and pericyclic approaches. The acquired tools are useful in the continuation of study in master 2 chemistry of bioactive molecules.

Acquire basic knowledge in cell biology, in pharmacology in close connection with chemistry (molecular interactions, relationship structure activity, ...) for the identification / use of therapeutic targets.

Chemical modification methods for surfaces and bio-interfaces for sensor applications in biology.

Approximation methods, solving of non linear equations, matrices eigenvalues and eigenvectors calculations. Resolution of linear systems, direct and iterative methods. Application to examples from matter sciences.

Perturbation and variations theories. Hartree-Fock method. Density Functional Theory. Configuration interaction. Introduction to statistics physics (partition functions, Boltzmann distribution, statistical formulations of thermodynamics values, Monte Carlo method).

Analysis of IR, UV, microwave and Raman spectra.

Modelisation in biological systems, solvation. Introduction to molecular dynamics, multi-scale modelisation.

Application of Flory's theories to methods of polymer characterization in solution (osmometry, viscometry, light scattering and size exclusion chromatography). Viscoelastic solutions and Gels

Operating principles of electrophoretic and electrochromatographic methods and their range of application in terms of biological / chemical compounds analyzed. Chromatographic methods dedicated to the analysis of biomolecules and biomacromolecules. Master sample preparation methods using miniaturized systems.